CELLECTRA®: Adaptive Electroporation Device


Originally developed for veterinary use, with thousands of animals in a dozen species safely and effectively treated to date
Extensive use and experience in thousands of animals
This treatment system includes a well-designed applicator and electrode arrays suitable for numerous applications and a rechargeable battery
CELLECTRA® device and components are water and shock proof, software-driven and designed for use in laboratory or field conditions
LCD with a contrast knob and backlight to easily depict EP parameters to reduce confusion and errors
Clear audio and visual cues mark progress of the treatment
Volume of audio cues can be increased for use in noisy environments
Plasmid or DNA vaccine injection can be delivered in the area delineated by the EP needles – a one step approach to injection & EP
The sterile EP needle array is changed after each individual treatment, and it is locked in place in the handle during the EP procedure


Features and highlights:
Research at VGX™ Pharmaceuticals has demonstrated that this technology increases plasmid uptake and, thus, expression by 1000-fold over plasmid injection alone, to levels comparable to those obtained using viral vectors
CELLECTRA® device delivers a constant-current electrical field that maintains a square-wave function through tissue – important for successful EP
The microprocessor-driven device is capable of measuring tissue resistance and adapting output to varying individual conditions, such as fat content in the muscle, skin thickness or changing tissue resistance during the EP process
CELLECTRA® device has built-in safety features, including an enabling step – an electric field will not be generated if the individual needles of EP needle- array are not inserted into the target tissue, and furthermore, into the same muscle
Virtual elimination of heat-related tissue damage, and consequently pain usually involved with traditional EP methods
System settings can be tailored to match your EP needs: depth of tissue penetration, electric field intensity, lag time between injection and EP, pulse duration, injection volume
CELLECTRA® device can instantly detect errors before the electroporation sequence is started, thus preventing waste of test substance
Machine maintains settings to avoid mistakes between treated animals – each animal number can be entered and stored in CELLECTRA®
EP data for each pulse in each treated subject is recorded, and with the help of built-in software, can be easily downloaded and analyzed
   


Applications:
Gene Delivery of GHRH platform in all veterinary species
Delivery of DNA vaccine platform
 



Caution:
Investigational device. Limited by Federal law to investigational use. These devices are not yet available for sale.



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